CPTH2 |CAS:357649-93-5 Probechem Biochemicals

Chemical Structure : CPTH2

CAS No.: 357649-93-5

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CPTH2 (GCN5 inhibitor CPTH2, CPTH-2)

货号: PC-35322Not For Human Use, Lab Use Only.

CPTH2 is a specific histone acetyltransferase inhibitor modulating Gcn5 network in vitro and in vivo, inhibits H3 acetylation and induces cell-cycle perturbation and apoptosis in U-937 cells.

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10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

CPTH2 is a specific histone acetyltransferase inhibitor modulating Gcn5 network in vitro and in vivo, inhibits H3 acetylation and induces cell-cycle perturbation and apoptosis in U-937 cells.
CPTH2 increases E1A CR3 transactivation of human adenovirus through inhibition of HAT GCN5.
CPTH2 also reduces virus yield during infection.
CPTH2 induces apoptosis and decreases the invasiveness of a ccRCC cell line through the inhibition of KAT3B.

物理化学性质&存储条件

分子量	291.797
分子式	C14H14ClN3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-(4-Chloro-phenyl)-thiazol-2-yl]-N'-cyclopentylidene-hydrazine

参考文献

1. Chimenti F, et al. J Med Chem. 2009 Jan 22;52(2):530-6.

2. Trisciuoglio D, et al. Clin Cancer Res. 2012 Jan 15;18(2):475-86.

3. Cocco E, et al. Clin Epigenetics. 2018 Apr 4;10:44.

4. Ablack JN, et al. J Virol. 2012 Aug;86(15):8198-209.

CPTH2 (GCN5 inhibitor CPTH2, CPTH-2)

生物&药学活性

物理化学性质&存储条件

参考文献

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CPTH2 (GCN5 inhibitor CPTH2, CPTH-2)

生物&药学活性

物理化学性质&存储条件

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