CPT157633 |CAS:888213-72-7 Probechem Biochemicals

Chemical Structure : CPT157633

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CPT157633 (CPT 157633;CPT-157633)

货号: PC-35178Not For Human Use, Lab Use Only.

CPT157633 is a novel potent, selective PTP1B inhibitor with Ki of 40 nM, shows markedly less activities against a panel of 6 PTPs and 2 dual-specificity phosphatases.

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生物&药学活性

CPT157633 is a novel potent, selective PTP1B inhibitor with Ki of 40 nM, shows markedly less activities against a panel of 6 PTPs and 2 dual-specificity phosphatases.
CPT157633 prevents binge drinking-induced glucose intolerance in vivo.
CPT157633 also ameliorates the X-linked neurological disorder Rett syndrome (RTT) phenotypes in male mouse models.

物理化学性质&存储条件

分子量	465.203
分子式	C12H16BrF2N2O6PS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Phosphonic acid, [[2-bromo-4-[(2S)-3-(methylamino)-2-[(methylsulfonyl)amino]-3-oxopropyl]phenyl]difluoromethyl]- (9CI)

参考文献

1. Lindtner C, et al. Sci Transl Med. 2013 Jan 30;5(170):170ra14.

2. Krishnan N, et al. J Clin Invest. 2015 Aug 3;125(8):3163-77.

CPT157633 (CPT 157633;CPT-157633)

生物&药学活性

物理化学性质&存储条件

参考文献

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CPT157633 (CPT 157633;CPT-157633)

生物&药学活性

物理化学性质&存储条件

参考文献

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