CPR1-B

Chemical Structure : CPR1-B

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货号: PC-49730Not For Human Use, Lab Use Only.

CPR1-B is a longer-acting phenylhexanamide mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.3 nM (Emax=89%).

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100 mg		Get quote

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生物&药学活性

CPR1-B is a longer-acting phenylhexanamide mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.3 nM (Emax=89%).
CPR1-B promotes the relaxed/active MFN2 conformation without affecting catalytic GTPase activity.
CPR1-B is a longer acting compound that can provide sustained mitofusin activation.
CPR1-B (60 mg/kg given orally twice daily) causes sustained mitofusin activation in 50-week-old MFN2 T105M mice.
CPR1-B modified phenotypes in vitro and in vivo in murine amyotrophic lateral sclerosis (ALS).
CPR1-B exhibits sustained brain levels, markedly prolonged pharmacodynamic effects, and disease modification in a proof-of-concept study of murine amyotrophic lateral sclerosis.

物理化学性质&存储条件

分子量	301.43
分子式	C19H27NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R)-N-((1s,4S)-4-hydroxycyclohexyl)-2-(3-phenylpropyl)cyclopropane-1-carboxamide

参考文献

1. Dang X, et al. J Med Chem 64:12506–12524.

2. Franco A, et al. J Pharmacol Exp Ther. 2022 Nov;383(2):137-148.

CPR1-B

生物&药学活性

物理化学性质&存储条件

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CPR1-B

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物理化学性质&存储条件

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