CPP-115 | GABA aminotransferase inhibitor | Probechem Biochemicals

Chemical Structure : CPP-115

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CPP-115 (CPP115)

货号: PC-62759Not For Human Use, Lab Use Only.

CPP-115 is an orally available, small molecule, next-generation GABA aminotransferase (GABA-AT) inhibitor with Ki of 31 uM, without other GABAergic or off-target activities.

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生物&药学活性

CPP-115 is an orally available, small molecule, next-generation GABA aminotransferase (GABA-AT) inhibitor with Ki of 31 uM, without other GABAergic or off-target activities.
CPP-115 displays superior enzyme inactivation properties compared to vigabatrin, decreases spasms in the multiple-hit rat model of infantile spasms.
CPP-115 deonstrates high therapeutic potential for the treatment of cocaine addiction and for a variety of epilepsies.

物理化学性质&存储条件

分子量	177.151
分子式	C7H9F2NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,3S)-3-amino-4-(difluoromethylidene)cyclopentane-1-carboxylic acid

参考文献

1. Pan Y, et al. J Med Chem. 2012 Jan 12;55(1):357-66.

2. Briggs SW, et al. Epilepsia. 2014 Jan;55(1):94-102.

3. Lee H, et al. J Am Chem Soc. 2015 Feb 25;137(7):2628-40.

4. Prescot AP, et al. Neuropsychopharmacology. 2018 Feb;43(3):646-654.

CPP-115 (CPP115)

生物&药学活性

物理化学性质&存储条件

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CPP-115 (CPP115)

生物&药学活性

物理化学性质&存储条件

参考文献

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