CPL304110 | FGFR inhibitor | Probechem Biochemicals

Chemical Structure : CPL304110

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CPL304110 (CPL-304110)

货号: PC-72218Not For Human Use, Lab Use Only.

CPL304110 (CPL-304110) is a selective and potent pan-FGFR inhibitor with IC50 of 0.75 nM, 0.50 nM, 3.05 nM against FGFR1, 2, 3, shows weaken acitvity against FGFR4 with IC50 of 87.9 nM.

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生物&药学活性

CPL304110 (CPL-304110) is a selective and potent pan-FGFR inhibitor with IC50 of 0.75 nM, 0.50 nM, 3.05 nM against FGFR1, 2, 3, shows weaken acitvity against FGFR4 with IC50 of 87.9 nM.
CPL304110 shows potent anti-tumor activity in vivo, CPL304110 is currently under evaluation in phase I clinical trial for the treatment of bladder, gastric and squamous cell lung cancers.

物理化学性质&存储条件

分子量	445.567
分子式	C26H31N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-(3,5-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazole

参考文献

1. Yamani A, et al. Eur J Med Chem. 2021 Jan 15;210:112990.

2. Kitowska K, et al. Front Oncol. 2021 Apr 7;11:633410.

3. Zarczynska I, et al. Cells. 2021 Nov 30;10(12):3363.

CPL304110 (CPL-304110)

生物&药学活性

物理化学性质&存储条件

参考文献

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CPL304110 (CPL-304110)

生物&药学活性

物理化学性质&存储条件

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