CPL207280 | GPR40 agonist | Probechem Biochemicals

Chemical Structure : CPL207280

加入收藏

CPL207280 (CPL 207280)

货号: PC-72119Not For Human Use, Lab Use Only.

CPL207280 (CPL 207280) is a novel potent, selective GPR40/FFA1 agonist with EC50 of 80 nM in a Ca2+ influx assay, shows greater potency than fasiglifam (EC50=270 nM).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CPL207280 (CPL 207280) is a novel potent, selective GPR40/FFA1 agonist with EC50 of 80 nM in a Ca2+ influx assay, shows greater potency than fasiglifam (EC50=270 nM).
CPL207280 did not demonstrate any activity on the related GPR receptors, i.e., GPR41 (FFA2), GPR43 (FFA3), GPR55, GPR119, GPR120, GPR142, PPARα, or PPARγ at 10 uM.
At 10 uM, CPL207280 showed 3.9 times greater enhancement of glucose-stimulated insulin secretion in mouse MIN6 pancreatic β-cells.
CPL207280 improved glucose tolerance and increased insulin area in diabetic rats. CPL207280 is a potent enhancer of glucose-stimulated insulin secretion in animal disease models with no risk of hypoglycemia at therapeutic doses.

物理化学性质&存储条件

分子量	286.371
分子式	C18H22O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(4-((2,3-dimethylbut-2-en-1-yl)oxy)phenyl)hex-4-ynoic acid

参考文献

1. Bazydlo-Guzenda K, et al. Mol Pharmacol. 2021 Oct;100(4):335-347.

2. Smuga D, et al. Eur J Med Chem. 2021 Dec 15;226:113810.

3. Bazydlo-Guzenda K, et al. PLoS One. 2021 Sep 23;16(9):e0257477.

CPL207280 (CPL 207280)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CPL207280 (CPL 207280)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.