CPK20 | KNa1.1 (Slack) inhibitor | Probechem Biochemicals

Chemical Structure : CPK20

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CPK20 (KCNT1 channel inhibitor CPK20)

货号: PC-22388Not For Human Use, Lab Use Only.

CPK20 is a potent, selective inhibitor / blocker of potassium (K+) channel KCNT1 (KNa1.1, Slo2.2, SLACK) with IC50 of 6.4 uM in fluorescence-based assay FluxOR.

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100 mg		Get quote

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生物&药学活性

CPK20 is a potent, selective inhibitor / blocker of potassium (K+) channel KCNT1 (KNa1.1, Slo2.2, SLACK) with IC50 of 6.4 uM in fluorescence-based assay FluxOR.
CPK20 (10 uM) blocked KCNT1 currents almost completely.
CPK20 is devoid of hERG-blocking activity.
CPK20 could block preferentially KCNT1 vs KCNT2 channels, and to exert a potent blocking effect over clinically-relevant pathogenic KCNT1 variants, thus revealing its potential as target therapy for patients affected by KCNT1-related epilepsies.

物理化学性质&存储条件

分子量	506.51
分子式	C23H24F6N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-{1-[2,4-Bis(trifluoromethyl)benzyl]indolin-5-yl}cyclohexanesulfonamide

参考文献

1. Nunzio Iraci, et al. Journal of Medicinal Chemistry, May 23, 2024.

CPK20 (KCNT1 channel inhibitor CPK20)

生物&药学活性

物理化学性质&存储条件

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CPK20 (KCNT1 channel inhibitor CPK20)

生物&药学活性

物理化学性质&存储条件

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