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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-CPI-1328
CPI-1328

Chemical Structure : CPI-1328

CAS No.: 2390367-27-6

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CPI-1328 (CPI 1328)

货号: PC-20857Not For Human Use, Lab Use Only.

CPI-1328 is a highly potent, selective EZH2 inhibitor with sub-pM binding affinitiy (Ki=63 fM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CPI-1328 is a highly potent, selective EZH2 inhibitor with sub-pM binding affinitiy (Ki=63 fM).
CPI-1328 exhibited dose-dependent reduction in H3K27me3 levels with 10 mg/kg QD CPI-1328 causing a 43% reduction in H3K27me3 levels and 25 mg/kg QD CPI-1328 causing an 89% reduction in H3K27me3 levels in mice.

物理化学性质&存储条件

分子量 546.12
分子式 C28H36ClN3O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

CC1=C2C(CCN(CC3=C(SC)C=C(C)NC3=O)C2=O)=C(Cl)C4=C1O[C@](C5CC[C@H](N(C)C)CC5)(C)O4

参考文献

1. Jacob I Stuckey, et al. J Biol Chem. 2021 Jan-Jun;296:100349.

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