CPI-1205 |Cas:1621862-70-1 Buy CPI-1205 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : CPI-1205

CAS No.: 1621862-70-1

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CPI-1205 (Lirametostat;CPI 1205;CPI1205)

货号: PC-60299Not For Human Use, Lab Use Only.

Lirametostat (CPI-1205) is a highly potent, selective EZH2 inhibitor with biochemical IC50 of 2 nM, cellular EC50 of 32 nM.

规格	价格	库存
10 mg	￥1980	In stock
25 mg	￥3680	In stock
50 mg	￥5980	In stock
100 mg	￥8980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Lirametostat (CPI-1205) is a highly potent, selective EZH2 inhibitor with biochemical IC50 of 2 nM, cellular EC50 of 32 nM.
Lirametostat (CPI-1205) demonstrates modest selectivity over EZH1 (IC50=52 nM), and a clean selectivity profile against 30 other histone or DNA methyltransferases.
Lirametostat (CPI-1205) exhibits robust antitumor effects in a Karpas-422 xenograft model (at 160 mg/kg BID).

物理化学性质&存储条件

分子量	518.57
分子式	C27H33F3N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide

参考文献

1. Vaswani RG, et al. J Med Chem. 2016 Nov 10;59(21):9928-9941.

CPI-1205 (Lirametostat;CPI 1205;CPI1205)

生物&药学活性

物理化学性质&存储条件

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CPI-1205 (Lirametostat;CPI 1205;CPI1205)

生物&药学活性

物理化学性质&存储条件

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