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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-CPI-0610
CPI-0610

Chemical Structure : CPI-0610

CAS No.: 1845726-14-8

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CPI-0610 (Pelabresib, CPI0610)

货号: PC-62282Not For Human Use, Lab Use Only.

Pelabresib (CPI-0610) is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay.

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10 mg ￥2280 In stock
25 mg ￥3680 In stock
50 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Pelabresib (CPI-0610) is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay.
Pelabresib (CPI-0610) is a shows remarkably selectivity, over the bromodomains of CBP, BRD9, BRPF1, PCAF, BRG1, ATAD2, TRIM24, BRD8.
Pelabresib (CPI-0610) is a has an IC50 of 0.18 uM in MYC RNA expression assay.
Pelabresib (CPI-0610) is a demonstrates antitumor efficacy in an MV-4-11 mouse xenograft model.

物理化学性质&存储条件

分子量 365.817
分子式 C20H16ClN3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[e]isoxazolo[5,4-c]azepin-4-yl)acetamide

参考文献

1. Albrecht BK, et al. J Med Chem. 2016 Feb 25;59(4):1330-9.

2. Siu KT, et al. Leukemia. 2017 Jan 3. doi: 10.1038/leu.2016.355.

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