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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Progesterone Receptor-CPAG-1
CPAG-1

Chemical Structure : CPAG-1

CAS No.: 2094991-62-3

CPAG-1 (PGRMC2 activator CPAG-1)

货号: PC-38286Not For Human Use, Lab Use Only.

CPAG-1 (PGRMC2 activator CPAG-1) is a small-molecule activator of PGRMC2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CPAG-1 (PGRMC2 activator CPAG-1) is a small-molecule activator of PGRMC2.
    CPAG-1 treatment had no effect on weight or food intake but treated mice had reduced fasting glycemia and insulin levels.
    CPAG-1 decreased Rev-Erbα protein in BAT of CPAG-1-treated mice.
    CPAG-1 also significantly increased labile heme in the nucleus of brown adipocytes from CPAG-1-treated mice within 4 days of treatment.

    物理化学性质&存储条件

    分子量 326.44
    分子式 C20H26N2O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-2-butyramido-4-methyl-N-(naphthalen-2-yl)pentanamide

    参考文献

    1. Andrea Galmozzi, et al. Nature. 2019 Dec;576(7785):138-142.

    2. Christopher G Parker, et al. Cell. 2017 Jan 26;168(3):527-541.e29.

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