CPA7 |CAS:16961-77-6 Probechem Biochemicals

Chemical Structure : CPA7

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CPA7 (STAT3 inhibitor CPA7;CPA-7)

货号: PC-60658Not For Human Use, Lab Use Only.

STAT3 inhibitor CPA7 is a platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells.

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1 g		Get quote

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生物&药学活性

STAT3 inhibitor CPA7 is a platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells.
CPA7 selectively and significantly inhibits Stat3 activation and DNA-binding activity, induces regression of colon tumors in mouse model at 5mg/kg, with the abrogation of persistent Stat3 activity in tumors.

物理化学性质&存储条件

分子量	381.501
分子式	Cl3H6N3O2Pt
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Platinum, diamminetrichloronitro- (8CI)

参考文献

1. Turkson J, et al. Mol Cancer Ther. 2004 Dec;3(12):1533-42.

2. Assi HH, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):458-69.

3. Littlefield SL, et al. Inorg Chem. 2008 Apr 7;47(7):2798-804.

4. Liang M, et al. BMC Cancer. 2016 Jul 19;16:504.

CPA7 (STAT3 inhibitor CPA7;CPA-7)

生物&药学活性

物理化学性质&存储条件

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CPA7 (STAT3 inhibitor CPA7;CPA-7)

生物&药学活性

物理化学性质&存储条件

参考文献

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