CP-9 | Hsp90α inhibitor | Probechem Biochemicals

Chemical Structure : CP-9

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CP-9 (Hsp90α/p23 inhibitor CP-9)

货号: PC-70362Not For Human Use, Lab Use Only.

CP-9 is a potent Hsp90α/p23 interaction inhibitor with IC50 of 3.2 uM, 5-fold less potent for Hsp90β/p23 interaction (IC50=15.3 uM).

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100 mg		Get quote

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生物&药学活性

CP-9 is a potent Hsp90α/p23 interaction inhibitor with IC50 of 3.2 uM, 5-fold less potent for Hsp90β/p23 interaction (IC50=15.3 uM).
CP-9 treatment leads to various levels of degradation of pAkt/total Akt and Raf-1 in cancer cell lines, but has no effect on the expression of the Hsp90 client proteins in normal mouse embryonic fibroblasts (MEFs).
CP-9 inhibits cell proliferation, glucose metabolism, and mammalian thymidine kinase activities in multiple cancer cell lines.

物理化学性质&存储条件

分子量	400.394
分子式	C15H11F3N4O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-methylisoxazol-3-yl)-2-[4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio]acetamide

参考文献

1. Chan CT, et al. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2476-85.

CP-9 (Hsp90α/p23 inhibitor CP-9)

生物&药学活性

物理化学性质&存储条件

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CP-9 (Hsp90α/p23 inhibitor CP-9)

生物&药学活性

物理化学性质&存储条件

参考文献

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