CP-628006 | CFTR potentiator | Probechem Biochemicals

Chemical Structure : CP-628006

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CP-628006 (CP628006)

货号: PC-72256Not For Human Use, Lab Use Only.

CP-628006 (CP628006) is a small molecule CFTR potentiator, potentiates low temperature-rescued F508del-CFTR with EC50 of 0.4 uM.

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生物&药学活性

CP-628006 (CP628006) is a small molecule CFTR potentiator, potentiates low temperature-rescued F508del-CFTR with EC50 of 0.4 uM.
CP-628006 potentiated wild-type (EC50=24 nM), F508del-CFTR (EC500=400 nM), and G551D-CFTR (EC50=380 nM) by increasing the frequency and duration of channel openings in excised inside-out membrane patches assays.
CP-628006 efficaciously potentiated CFTR function in epithelia from cultured hBE cells. Its effects on the predominant CFTR variant F508del-CFTR were larger than those with the gating variant G551D-CFTR.
Combinations of CP-628006 and ivacaftor enhances the potentiation of G551D-CFTR, but not F508del-CFTR.
CP-628006 restores ATP-dependent channel gating to G551D-CFTR.
CP-628006 efficaciously potentiated the CFTR-mediated Cl− currents of plasma membrane-rescued F508del- and G551D-CFTR.

物理化学性质&存储条件

分子量	536.639
分子式	C32H35F3N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4bS,7S,8aR)-4b-benzyl-7-hydroxy-N-((2-methylpyridin-3-yl)methyl)-7-(3,3,3-trifluoropropyl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-2-carboxamide

参考文献

1. Jia Liu, et al. Br J Pharmacol. 2021 Oct 13.

CP-628006 (CP628006)

生物&药学活性

物理化学性质&存储条件

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CP-628006 (CP628006)

生物&药学活性

物理化学性质&存储条件

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