CP-481715 |CAS:212790-31-3 Probechem Biochemicals

Chemical Structure : CP-481715

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CP-481715 (CP481715)

货号: PC-61967Not For Human Use, Lab Use Only.

CP-481715 is a potent and selective CCR1 antagonist with Ki of 9.2 nM and IC50 of 74 nM, lacks intrinsic agonist activity.

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生物&药学活性

CP-481715 is a potent and selective CCR1 antagonist with Ki of 9.2 nM and IC50 of 74 nM, lacks intrinsic agonist activity.
CP-481715 displays >100-fold selectiveity over a panel of GPCRs including related chemokine receptors.
CP-481715 fully blocks the ability of CCL3 and CCL5 to stimulate receptor signaling (calcium mobilization, IC50=71 nM), monocyte chemotaxis, IC50= 55 nM, and MMP 9 release, IC50= 54 nM).
CP-481715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice.

物理化学性质&存储条件

分子量	482.556
分子式	C26H31FN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(2S,3S,5R)-5-carbamoyl-1-(3-fluorophenyl)-3,8-dihydroxy-8-methylnonan-2-yl]quinoxaline-2-carboxamide

参考文献

1. Gladue RP, et al. J Biol Chem. 2003 Oct 17;278(42):40473-80.

2. Gladue RP, et al. J Immunol. 2006 Mar 1;176(5):3141-8.

3. Gilchrist A, et al. Br J Pharmacol. 2014 Nov;171(22):5127-38.

CP-481715 (CP481715)

生物&药学活性

物理化学性质&存储条件

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CP-481715 (CP481715)

生物&药学活性

物理化学性质&存储条件

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