CP-346086 | MTP inhibitor | Probechem Biochemicals

Chemical Structure : CP-346086

CAS No.: 186390-48-7

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CP-346086 (CP 346086, CP346086)

货号: PC-60675Not For Human Use, Lab Use Only.

CP-346086 is a potent, orally active microsomal triglyceride transfer protein (MTP) inhibitor that inhibits both human and rodent MTP with IC50 of 2 nM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

CP-346086 is a potent, orally active microsomal triglyceride transfer protein (MTP) inhibitor that inhibits both human and rodent MTP with IC50 of 2 nM.
CP-346086 inhibits apolipoprotein B (apoB) and triglyceride secretion (IC50=2.6 nM) without affecting apoA-I secretion or lipid synthesis.
CP-346086 lowers total, VLDL, and LDL cholesterol and triglycerides in rats.

物理化学性质&存储条件

分子量	477.491
分子式	C26H22F3N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((1H-1,2,4-triazol-5-yl)methyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamide

参考文献

1. Chandler CE, et al. J Lipid Res. 2003 Oct;44(10):1887-901.

2. Lamant M, et al. J Biol Chem. 2006 Nov 24;281(47):36289-302.

3. Kim E, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85.

CP-346086 (CP 346086, CP346086)

生物&药学活性

物理化学性质&存储条件

参考文献

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CP-346086 (CP 346086, CP346086)

生物&药学活性

物理化学性质&存储条件

参考文献

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