CP-339818 |CAS:478341-55-8 Probechem Biochemicals

Chemical Structure : CP-339818

CAS No.: 478341-55-8

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CP-339818 (CP339818)

货号: PC-62919Not For Human Use, Lab Use Only.

CP-339818 is a potent, selective, non-peptide KV1.3 channel antagonist with IC50 of 200 nM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1380	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

CP-339818 is a potent, selective, non-peptide KV1.3 channel antagonist with IC50 of 200 nM.
CP-339818 displays selectivity over Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2, with only exception Kv1.4 (IC50=300 nM), also has no effect on T cell channels (I(CRAC) and intermediate-conductance K(Ca)).
CP-339818 inhibits Kv1.3 in a use-dependent manner by preferentially blocking the C-type inactivated state of the channel; suppresses human T cell activation.

物理化学性质&存储条件

分子量	340.895
分子式	C21H25ClN2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1 pentanamine hydrochloride

参考文献

1. Nguyen A, et al. Mol Pharmacol. 1996 Dec;50(6):1672-9.

2. Jäger H, et al. J Physiol. 1998 Jan 15;506 ( Pt 2):291-301.

3. Lee YT, et al. Eur J Pharmacol. 2008 Feb 26;581(1-2):97-104.

CP-339818 (CP339818)

生物&药学活性

物理化学性质&存储条件

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CP-339818 (CP339818)

生物&药学活性

物理化学性质&存储条件

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