CP-100356 hydrochloride | P-gp inhibitor | Probechem Biochemicals

Chemical Structure : CP-100356 hydrochloride

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CP-100356 hydrochloride (CP100356)

货号: PC-72608Not For Human Use, Lab Use Only.

CP-100356 hydrochloride (CP100356) is a specific P-glycoprotein (P-gp) inhibitor, suppresses VSV-LASVGP, LCMV, and LASV infection with IC50 of 0.52, 0.54, and 0.062 uM, respectively, without significant cytotoxicity.

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1 g		Get quote

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生物&药学活性

CP-100356 hydrochloride (CP100356) is a specific P-glycoprotein (P-gp) inhibitor, suppresses VSV-LASVGP, LCMV, and LASV infection with IC50 of 0.52, 0.54, and 0.062 uM, respectively, without significant cytotoxicity.
CP100356 did not block receptor binding at the cell surface, it inhibited low-pH-dependent membrane fusion mediated by arenavirus glycoproteins.
CP-100356 is an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux was examined in the rat.
CP-100356 inhibited acetoxymethyl calcein (calcein-AM) uptake (IC50= 0.5 uM) and digoxin transport (IC50=1.2 uM) in human MDR1-transfected MDCKII cells.

物理化学性质&存储条件

分子量	597.109
分子式	C31H37ClN4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-(3,4-dimethoxyphenethyl)-6,7-dimethoxyquinazolin-2-amine hydrochloride

参考文献

1. Takenaga T, et al. Viruses. 2021 Sep 3;13(9):1763.

2. Kalgutkar AS, et al. J Pharm Sci. 2009 Dec;98(12):4914-27.

CP-100356 hydrochloride (CP100356)

生物&药学活性

物理化学性质&存储条件

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CP-100356 hydrochloride (CP100356)

生物&药学活性

物理化学性质&存储条件

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