COH29 | Ribonucleotide reductase inhibitor | Probechem Biochemicals

Chemical Structure : COH29

CAS No.: 1190932-38-7

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COH29 (RNR inhibitor COH29)

货号: PC-45751Not For Human Use, Lab Use Only.

COH29 is a small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM.

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5 mg	￥1580	In stock
10 mg	￥2380	In stock
25 mg	￥3680	In stock
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100 mg		Get quote

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生物&药学活性

COH29 is a small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM.
COH29 overcomes hydroxyurea and gemcitabine resistance in cancer cells, effectively inhibits proliferation of most cell lines in the NCI 60 human cancer panel.
COH29 inhibits nonhomologous end joining (NHEJ) efficiency in HCC1937 cells.
COH29 reduced tumor growth in mouse xenograft models of human cancer.

物理化学性质&存储条件

分子量	420.4378
分子式	C22H16N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	Benzamide,N-[4-(3,4-dihydroxyphenyl)-5-phenyl-2-thiazolyl]-3,4-dihydroxy-

参考文献

1. Zhou B, et al. Cancer Res. 2013 Nov 1;73(21):6484-93.

2. Chen MC, et al. Mol Pharmacol. 2015 Jun;87(6):996-1005.

3. Zhang H, et al. BMC Cancer. 2014 Sep 11;14:664.

COH29 (RNR inhibitor COH29)

生物&药学活性

物理化学性质&存储条件

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COH29 (RNR inhibitor COH29)

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