COH000 | CAS: 1534358-79-6 Probechem Biochemicals

Chemical Structure : COH000

CAS No.: 1534358-79-6

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COH000 (COH-000;COH 000;CID 46835111;SID 99212997)

货号: PC-35900Not For Human Use, Lab Use Only.

COH000 (COH-000) is a highly selective, first-in-class, irreversible, allosteric, covalent inhibitor of SUMO-Activating Enzyme E1, inhibits SUMOylation in vitro with IC50 of 0.2 uM, displays >500-fold selectivity for SUMOylation over ubiquitylation.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

COH000 (COH-000) is a highly selective, first-in-class, irreversible, allosteric, covalent inhibitor of SUMO-Activating Enzyme E1, inhibits SUMOylation in vitro with IC50 of 0.2 uM, displays >500-fold selectivity for SUMOylation over ubiquitylation.
COH000 increased the degradation of SAE2, increases the expression of miR-34b and reduces c-Myc levels in lymphoma and colorectal cancer cell lines and a colorectal cancer xenograft mouse model.

物理化学性质&存储条件

分子量	419.477
分子式	C25H25NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	dimethyl 1-((R)-1-(phenylamino)-2-(p-tolyl)ethyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate

参考文献

1. Li YJ, et al. Cell Chem Biol. 2018 Dec 5. pii: S2451-9456(18)30386-6. doi: 10.1016/j.chembiol.2018.10.026.

COH000 (COH-000;COH 000;CID 46835111;SID 99212997)

生物&药学活性

物理化学性质&存储条件

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COH000 (COH-000;COH 000;CID 46835111;SID 99212997)

生物&药学活性

物理化学性质&存储条件

参考文献

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