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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-AMPK-COH-SR4
COH-SR4

Chemical Structure : COH-SR4

CAS No.: 73439-19-7

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COH-SR4 (Mitochondria uncoupler SR4)

货号: PC-36018Not For Human Use, Lab Use Only.

COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling.

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50 mg ￥580 In stock
100 mg ￥980 In stock
250 mg ￥1480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling.
COH-SR4 prevents cell proliferation and promoted cell death in many human cancers including leukemia, lung cancer, melanoma, and hepatocarcinoma in vitro and in animal models.
COH-SR4 exhibits a strong inhibitory effect on the survival of melanoma cells (B16-F0 cell line IC50=5 uM, Hs600T cell lineI C50=6 uM, and A2058 cell line IC50=11 uM), does not cause any significant cytotoxicity in normal human aortic vascular smooth muscle cells (HAVSMC).
COH-SR4 inhibits vemurafenib-resistant melanoma in vivo.

物理化学性质&存储条件

分子量 350.02
分子式 C13H8Cl4N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,3-bis(3,5-dichlorophenyl)urea

参考文献

1. Singhal SS, et al. Biochem Pharmacol. 2012 Dec 1;84(11):1419-27.

2. Figarola JL, et al. Oncotarget. 2018 Dec 11;9(97):36945-36965.

3. Singhal SS, et al. Biochem Pharmacol. 2013 Dec 15;86(12):1664-72.

4. Figarola JL, et al. PLoS One. 2013 Dec 20;8(12):e83801.

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