COE2-2hexyl | S. aureus inhibitor | Probechem Biochemicals

Chemical Structure : COE2-2hexyl

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COE2-2hexyl (S. aureus inhibitor)

货号: PC-49758Not For Human Use, Lab Use Only.

COE2-2hexyl is a broad-spectrum antibacterial conjugated oligoelectrolyte (COE), does not evoke bacterial resistance, inhibits methicillin-resistant S. aureus (MRSA, MT3302) with MIC of 1 ug/mL.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

COE2-2hexyl is a broad-spectrum antibacterial conjugated oligoelectrolyte (COE), does not evoke bacterial resistance, inhibits methicillin-resistant S. aureus (MRSA, MT3302) with MIC of 1 ug/mL.
COE2-2hexyl effectively killed both S. Typhimurium 14028 (MIC=2 ug/mL) and CA-MRSA USA300 (MIC=1 ug/mL), with bactericidal activity kinetics similar to that of ciprofloxacin (CIP) treatment.
COE2-2hexyl effectively treated mice infected with multidrug-resistant (MDR) bacteria and was not prone to bacterial resistance.
COE2-2hexyl exhibited broad-spectrum antibacterial activity, showed low cytotoxicity in cultured mammalian cells.

物理化学性质&存储条件

分子量	1601.47
分子式	C70H132I4N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Hexanaminium, 6,6′,6′′,6′′′-[(1E)-1,2-ethenediylbis[5,1,3-benzenetriylbis(oxy)]]tetrakis[N-hexyl-N,N-dimethyl-, iodide (1:4)

参考文献

1. Douglas M Heithoff, et al. EBioMedicine. 2023 Feb 14;104461.