COB223 | Angiogenesis inhibitor | Probechem Biochemicals

Chemical Structure : COB223

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COB223 (COB 223, COB-223)

货号: PC-20705Not For Human Use, Lab Use Only.

COB223 is a chemical inhibitor of angiogenesis and tumorigenesis, targets the VEGF signaling pathway upstream of Ras, inhibits endothelial cell migration with IC50 of 5 uM.

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生物&药学活性

COB223 is a chemical inhibitor of angiogenesis and tumorigenesis, targets the VEGF signaling pathway upstream of Ras, inhibits endothelial cell migration with IC50 of 5 uM.
COB223 inhibits endothelial cell migration and proliferation.
COB223 inhibits also Lewis lung carcinoma (LLC/2) cell proliferation whereas it does not affect fibroblast proliferation.
COB223 (4 mg/kg, i.p.) efficiently reduced the tumor growth rate in a mouse LLC/2 tumor model.
COB223 inhibits endothelial cell ERK1/2 phosphorylation induced by VEGF, FGF-2 or serum and that it acts downstream of PKC and upstream of Ras.

物理化学性质&存储条件

分子量	533.73
分子式	C27H43N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(OC(C)(C)C)NCCCN1CCN(CCCNS(=O)(C2=C3C=CC=C(N(C)C)C3=CC=C2)=O)CC1

参考文献

1. Agnès Desroches-Castan, et al. Oncotarget. 2015 Mar 10;6(7):5382-411.

2. Marie Arvin-Berod, et al. ACS Omega. 2017 Dec 31;2(12):9221-9230.

COB223 (COB 223, COB-223)

生物&药学活性

物理化学性质&存储条件

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COB223 (COB 223, COB-223)

生物&药学活性

物理化学性质&存储条件

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