CNS-11

Chemical Structure : CNS-11

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货号: PC-49766Not For Human Use, Lab Use Only.

CNS-11 is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core.

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生物&药学活性

CNS-11 is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core.
CNS-11 is more predictive of oral bioavailability and central nervous system penetration compared to EGCG.
CNS-11 (10 uM) inhibits intracellular seeding in alpha-synuclein biosensor cells and mitigation of alpha-synuclein cytotoxicity.
CNS-11 disaggregates MSA patient brain-derived alpha-synuclein fibrils in vitro, reduces alpha-synuclein aggregates in C. elegans, also could penetrate brain tissue in mice.

物理化学性质&存储条件

分子量	395.46
分子式	C25H21N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-mesityl-2-(3-oxoindeno[1,2,3-de]phthalazin-2(3H)-yl)acetamide

参考文献

1. Murray KA, et al. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2217835120.

CNS-11

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CNS-11

生物&药学活性

物理化学性质&存储条件

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