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首页-小分子抑制剂&激动剂-Others-Other Targets-CNOT6L inhibitor iD1
CNOT6L inhibitor iD1

Chemical Structure : CNOT6L inhibitor iD1

CAS No.: 517-89-5

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CNOT6L inhibitor iD1 (Inhibitor of CNOT6L Deadenylase 1, ICCB-475)

货号: PC-23518Not For Human Use, Lab Use Only.

CNOT6L inhibitor iD1 (Inhibitor of CNOT6L Deadenylase 1, ICCB-475) is a specific small molecule inhibitor of CCR4-NOT deadenylase subunit CNOT6L with Kd of 7.6 uM and IC50 of 2.5 uM in FRET-based deadenylase assay, modestly inhibits homolog CNOT6 and does not inhibit CNOT7 or CNOT8.

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10 mg ￥3980 In stock
25 mg ￥5980 In stock
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生物&药学活性

CNOT6L inhibitor iD1 (Inhibitor of CNOT6L Deadenylase 1, ICCB-475) is a specific small molecule inhibitor of CCR4-NOT deadenylase subunit CNOT6L with Kd of 7.6 uM and IC50 of 2.5 uM in FRET-based deadenylase assay, modestly inhibits homolog CNOT6 and does not inhibit CNOT7 or CNOT8.
iD1 stabilizes hepatic GDF15 and FGF21 mRNAs, increasing levels of Gdf15 and Fgf21 mRNAs in primary hepatocytes as well as GDF15 and FGF21 mRNAs in Huh7 cells with EC50 of 1.11 μM, 2.08 μM, 0.530 μM, and 1.61 μM, respectively.
iD1 decreases body weight by reducing food intake and enhancing energy expenditure and fat utilization, with EC50 of 1.43 and 1.23 mg/kg for food intake and body weight, respectively.
iD1 demonstrates enhancing GDF15 and FGF21 hepatokine levels, which dramatically improves diet-induced metabolic syndrome.
The CCR4-NOT complex consists of 8 subunits, including two deadenylase catalytic subunits CNOT6/CNOT6L and CNOT7/CNOT8, a scaffold protein CNOT1, and regulatory subunits CNOT2, CNOT3, CNOT9, CNOT10, and CNOT11, CNOT6/CNOT6L is defined as the predominant factor for mRNA deadenylation.

物理化学性质&存储条件

分子量 288.30
分子式 C16H16O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione

参考文献

1. Katsumura S, et al. Cell Metab. 2022 Apr 5;34(4):564-580.e8.

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