CNBDA | SHP2 inhibitor | Probechem Biochemicals

Chemical Structure : CNBDA

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CNBDA (SHP2 inhibitor CNBDA)

货号: PC-72033Not For Human Use, Lab Use Only.

CNBDA is a novel selective Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitor with IC50 of 5 uM, 25-fold selectivity over SHP1.

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生物&药学活性

CNBDA is a novel selective Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitor with IC50 of 5 uM, 25-fold selectivity over SHP1.
Treatment HER2-positive BC cells with CNBDA suppressed cell proliferation in 2D culture, anchorage-independent growth in soft agar, and mammosphere (tumorisphere) formation in suspension cultures in a concentration-dependent manner.
CNBDA inhibited EGF-induced signaling and expression of HER2 by inhibiting the PTPase activity of SHP2 in BC cells.

物理化学性质&存储条件

分子量	512.643
分子式	C30H40O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4'-(4'-carboxy-4-(nonyloxy)-[1,1'-biphenyl]-3,5-diyl)dibutyric acid

参考文献

1. Zachary Hartman, et al. ACS Omega. 2020 Sep 25;5(39):25113-25124.

CNBDA (SHP2 inhibitor CNBDA)

生物&药学活性

物理化学性质&存储条件

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CNBDA (SHP2 inhibitor CNBDA)

生物&药学活性

物理化学性质&存储条件

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