CNBCA

Chemical Structure : CNBCA

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货号: PC-20975Not For Human Use, Lab Use Only.

CNBCA is a selective, competitive inhibitor of Src homology phosphotyrosyl phosphatase 2 (SHP2) with IC50 of 0.87 uM, effectively suppresses breast cancer cell phenotypes.

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生物&药学活性

CNBCA is a selective, competitive inhibitor of Src homology phosphotyrosyl phosphatase 2 (SHP2) with IC50 of 0.87 uM, effectively suppresses breast cancer cell phenotypes.
CNBCA shows good selectivity (>25-fold) over SHP1 and PTP1B in the phosphatase assays.
CNBCA binds to endogenous full-length SHP2 under cellular contexts, inhibits FL-SHP2 with IC50 of 0.615 uM in PTPase assays.
CNBCA effectively downregulates SHP2 mediated signaling in breast cancer (BC) cells, inhibits SHP2 mediated Akt and ERK1/2 activation in the BT474 and MDA-MB468 cells with IC50 of 1 uM.
CNBCA (500 nM) is effective in suppressing the cancer stem cell properties of BC cells.

物理化学性质&存储条件

分子量	426.55
分子式	C26H34O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=CC=C(C2=CC=C(OCCCCCCCCC)C(CCCC(O)=O)=C2)C=C1)O

参考文献

1. Dhanaji M. Lade, et al. ACS Bio Med Chem Au 2023

CNBCA

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物理化学性质&存储条件

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CNBCA

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物理化学性质&存储条件

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