欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-CMX410
CMX410

Chemical Structure : CMX410

CAS No.: 3027135-80-1

加入收藏

CMX410 (CMX-410)

货号: PC-25221Not For Human Use, Lab Use Only.

CMX410 (CMX-410) is a potent, specific, irreversible inhibitor of Mycobacterium tuberculosis (Mtb) Pks13, targets the acyltransferase domain of Pks13, an essential enzyme in cell-wall biosynthesis, inhibits MABA H37Rv strain with MIC90 of 39 nM and MBC of 78 nM.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CMX410 (CMX-410) is a potent, specific, irreversible inhibitor of Mycobacterium tuberculosis (Mtb) Pks13, targets the acyltransferase domain of Pks13, an essential enzyme in cell-wall biosynthesis, inhibits MABA H37Rv strain with MIC90 of 39 nM and MBC of 78 nM.
CMX410 shows potent activity against all Mtb strains tested, including XDR clinical isolates, with reduced activity for non-TB mycobacteria and inactivity against a panel of gram-positive and gram-negative bacteria.
CMX410 (25-100 mg/kg QD) is active in acute TB infection in BALB/c mice.
CMX410 represents the most advanced inhibitor developed to target and inhibit Pks13 or any other polyketide synthase.

物理化学性质&存储条件

分子量 478.42
分子式 C16H13F3N4O6S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((2,6-difluoro-4-(3-(methylsulfonamido)-1H-1,2,4-triazol-1-yl)benzyl)oxy)phenyl sulfurofluoridate

参考文献

1. Krieger IV, et al. Nature. 2025 Jul 30. doi: 10.1038/s41586-025-09286-3.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: