CMPD167 (MRK-1) | CCR5 antagonist | Probechem Biochemicals

Chemical Structure : CMPD167

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CMPD167 (CMPD 167, MRK-1)

货号: PC-61964Not For Human Use, Lab Use Only.

CMPD167 (MRK-1) is an orally acitve small molecule that binds to CCR5 to inhibit gp120 association, inhibits different stages of the virus-cell attachment and entry process (CCR5-using virus SHIV-162P3, IC50<1 nM).

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生物&药学活性

CMPD167 (MRK-1) is an orally acitve small molecule that binds to CCR5 to inhibit gp120 association, inhibits different stages of the virus-cell attachment and entry process (CCR5-using virus SHIV-162P3, IC50<1 nM).

物理化学性质&存储条件

分子量	574.785
分子式	C35H47FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1R,3S,4S)-3-((4-(3-benzyl-1-ethyl-1H-pyrazol-5-yl)piperidin-1-yl)methyl)-4-(3-fluorophenyl)cyclopentyl)-N-methyl-D-valine

参考文献

1. Veazey RS, et al. Nature. 2005 Nov 3;438(7064):99-102.

2. Veazey RS, et al. Nat Med. 2005 Dec;11(12):1293-4.

3. Ketas TJ, et al. Virology. 2007 Aug 1;364(2):431-40.

4. Malcolm RK, et al. Antimicrob Agents Chemother. 2012 May;56(5):2251-8.

CMPD167 (CMPD 167, MRK-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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CMPD167 (CMPD 167, MRK-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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