CMP05 | Endosomolytic compound | Probechem Biochemicals

Chemical Structure : CMP05

CAS No.:

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CMP05 (Endosomolytic compound CMP05)

货号: PC-72946Not For Human Use, Lab Use Only.

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生物&药学活性

CMP05 (Endosomolytic compound CMP05) is a novel endosomolytic small-molecule compound that exhibits higher transfection efficiency/ability to induce endosomal escape of oligonucleotides (ONs) than current compounds such as chloroquine.
CMP05 had significantly higher efficacy than CMP01 at 5 uM, increased Splice-switching ON (SSO) activity.
CMP05 induced SSO leakage concurrently with endosomal swelling, induced SSO leakage in a mCherry-GAL9-recruitment-dependent manner.
CMP05 disrupted normal SSO trafficking through the endosomal network.
CMP05 was able to increase ON activity in a more efficacious manner than the previously published compound, UNC2383, in HeLa and HuH7 cell lines.

物理化学性质&存储条件

分子量	448.915
分子式	C22H21ClN8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-chloro-2-((3-methoxy-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-1H-indole-4-carbonitrile

参考文献

1. Jeremy P Bost, et al. Commun Biol. 2022 Mar 1;5(1):185.

CMP05 (Endosomolytic compound CMP05)

生物&药学活性

物理化学性质&存储条件

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CMP05 (Endosomolytic compound CMP05)

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物理化学性质&存储条件

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