CMM-98 | OGG1 activator | Probechem Biochemicals

Chemical Structure : CMM-98

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CMM-98 (CMM98)

货号: PC-28421Not For Human Use, Lab Use Only.

CMM-98 is a specific small molecule modulator / activator of DNA glycosylase OGG1 with AC50 of 38 nM and 83 nM on hOGG1 and mOGG1 respectively.

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生物&药学活性

CMM-98 is a specific small molecule modulator / activator of DNA glycosylase OGG1 with AC50 of 38 nM and 83 nM on hOGG1 and mOGG1 respectively.
CMM-98 installs a robust AP-site processing function in the DNA glycosylase OGG1 by binding the active site.
CMM-98 effectively rewires the enzyme's catalytic outcome under oxidative stress, boosting AP site turnover by 57‐fold.
CMM-98 reduces oxidative DNA damage burden, promotes the resolution of oxidative DNA lesions, and ameliorates hepatocyte injury.
CMM-98 exhibits selectivity against representative DNA glycosylases and a wider kinase panel.

物理化学性质&存储条件

分子量	320.40
分子式	C18H20N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-methyl-N4-phenyl-N2-(2-(pyridin-3-ylamino)ethyl)pyrimidine-2,4-diamine

参考文献

1. Zhao Z, et al. Adv Sci (Weinh). 2026 Sep 27:e77956.

CMM-98 (CMM98)

生物&药学活性

物理化学性质&存储条件

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CMM-98 (CMM98)

生物&药学活性

物理化学性质&存储条件

参考文献

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