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首页-小分子抑制剂&激动剂-Others-Human Antigen R (HuR)-CMLD-2
CMLD-2

Chemical Structure : CMLD-2

CAS No.: 958843-91-9

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CMLD-2 (CMLD 2, CMLD2)

货号: PC-60911Not For Human Use, Lab Use Only.

CMLD-2 is a small molecule disruptor of HuR-mRNA interaction with Ki of 350 nM.

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5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CMLD-2 is a small molecule disruptor of HuR-mRNA interaction with Ki of 350 nM.
CMLD-2 causes G1 phase cell-cycle arrest and induces apoptosis in NSCLC cells, decreases HuR mRNA and the mRNAs of HuR-regulated proteins (Bcl2 and p27).
CMLD-2 displays cytotoxic selectivity on cancer cells and blocks HuR protein bound to Msi1 and XIAP mRNAs, thereby decreasing target mRNA stability and protein levels as well as inhibiting the Wnt signaling pathway.

物理化学性质&存储条件

分子量 513.59
分子式 C31H31NO6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5,7-dimethoxy-8-(1-(4-methoxyphenyl)-3-oxo-3-(pyrrolidin-1-yl)propyl)-4-phenyl-2H-chromen-2-one

参考文献

1. Muralidharan R, et al. Sci Rep. 2017 Aug 30;7(1):9694.

2. Wu X, et al. ACS Chem Biol. 2015 Jun 19;10(6):1476-84.

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