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首页-小分子抑制剂&激动剂-Others-Other Targets-CMA-008
CMA-008

Chemical Structure : CMA-008

CAS No.: 854091-96-6

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CMA-008 (CMA008)

货号: PC-62062Not For Human Use, Lab Use Only.

CMA-008 is a cell-permeable, small molecule modulator of NAADP-mediated Ca2+ release, competes with NAADP binding, inhibits Ca2+ release via the NAADP receptor (IC50=15 uM-1 mM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CMA-008 is a cell-permeable, small molecule modulator of NAADP-mediated Ca2+ release, competes with NAADP binding, inhibits Ca2+ release via the NAADP receptor (IC50=15 uM-1 mM).
    CMA-008 selectively ablates NAADP-dependent Ca2+ oscillations induced by the external gastric peptide hormone agonist cholecystokinin (CCK) in murine pancreatic acinar cells.

    物理化学性质&存储条件

    分子量 308.075
    分子式 C8H9IN2O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-carbamoylmethyl-3-carboxy pyridinium iodide

    参考文献

    1. Dowden J, et al. Chem Biol. 2006 Jun;13(6):659-65.

    2. Dammermann W, et al. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10678-83.

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