CM03 | G-quadruplex binder | Probechem Biochemicals

Chemical Structure : CM03

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CM03 (G-quadruplex binder CM03)

货号: PC-62506Not For Human Use, Lab Use Only.

CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM).

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生物&药学活性

CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM).
CM03 shows >20-fold selectivity for MIA PaCa-2 compared to MCF-7 cells, also shows greater selectivity than MM41 relative to the non-oncogenic control fibroblasts.
CM03 demonstrates anticancer activity in PDAC models, with a superior profile compared to gemcitabine.

物理化学性质&存储条件

分子量	632.762
分子式	C34H44N6O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,7-bis(3-morpholinopropyl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone

参考文献

1. Marchetti C, et al. J Med Chem. 2018 Feb 7. doi: 10.1021/acs.jmedchem.7b01781.

CM03 (G-quadruplex binder CM03)

生物&药学活性

物理化学性质&存储条件

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CM03 (G-quadruplex binder CM03)

生物&药学活性

物理化学性质&存储条件

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