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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-CM-675
CM-675

Chemical Structure : CM-675

CAS No.: 1872466-47-1

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CM-675 (CM675, CM 675)

货号: PC-35926Not For Human Use, Lab Use Only.

CM-675 (CM675) is a potent, dual PDE5 and classI-HDAC inhibitor with IC50 of 114/673 nM for PDE5A/HDAC1, respectively.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CM-675 (CM675) is a potent, dual PDE5 and classI-HDAC inhibitor with IC50 of 114/673 nM for PDE5A/HDAC1, respectively.
CM-675 displays >10-fold selectivity over HDAC6.
CM-675 induces significant cellular responses (AcH3K9 and pCREB) at low concentrations (26-100 nM) with little cytotoxicity.
CM-675 shows an adequate ADME-Tox profile and in vivo target engagement (histone acetylation and cAMP/cGMP response element-binding (CREB) phosphorylation) in the central nervous system (CNS).

物理化学性质&存储条件

分子量 536.636
分子式 C31H32N6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-aminophenyl)-4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]benzamide

参考文献

1. Rabal O, et al. ACS Chem Neurosci. 2018 Dec 10. doi: 10.1021/acschemneuro.8b00648.

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