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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Chloride Channel-CLP290
CLP290

Chemical Structure : CLP290

CAS No.: 1181083-81-7

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CLP290 (CLP-290)

货号: PC-35775Not For Human Use, Lab Use Only.

CLP290 (CLP-290) is an orally acirtve small molecule K+-Cl- cotransporter isotype 2 (KCC2) activator, the carbamate prodrug of CLP257.

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25 mg ￥1980 In stock
50 mg ￥2980 In stock
100 mg ￥4880 In stock
200 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CLP290 (CLP-290) is an orally acirtve small molecule K+-Cl- cotransporter isotype 2 (KCC2) activator, the carbamate prodrug of CLP257.
In vivo co-treatment with morphine and oral CLP290 prevented membrane KCC2 downregulation in SDH neurons.
Co-treatment with CLP290 significantly mitigated MIH and acute administration of CLP257 in established MIH restored normal nociceptive behavior.

物理化学性质&存储条件

分子量 404.46
分子式 C19H21FN4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

[5-Fluoro-2-[(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methyl]phenyl] pyrrolidine-1-carboxylate

参考文献

1. Chen B, et al. Cell. 2018 Jul 26;174(3):521-535.e13.

2. Ferrini F, et al. Sci Rep. 2017 Jun 20;7(1):3870.

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