CLOCK inhibitor CLK8

Chemical Structure : CLOCK inhibitor CLK8

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货号: PC-49460Not For Human Use, Lab Use Only.

CLOCK inhibitor CLK8 is a CLOCK-binding small molecule disrupting the interaction between CLOCK and BMAL1, interferes with nuclear translocation of CLOCK both in vivo and in vitro.

规格	价格	库存	数量
10 mg		Get quote
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CLOCK inhibitor CLK8 is a CLOCK-binding small molecule disrupting the interaction between CLOCK and BMAL1, interferes with nuclear translocation of CLOCK both in vivo and in vitro.
CLK8 binds in the hollow created between the α2 helix of the bHLH domain and the Hβ strand of the PAS-A domain of CLOCK.
CLK8 alters CLOCK protein levels in a time-dependent manner in U2OS cells.
CLK8 (25 mg/kg, i.p.) enhances the amplitude of the circadian rhythm with no change in period length in treated mice.

物理化学性质&存储条件

分子量	498.535
分子式	C29H26N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-((8,8-dimethyl-2-oxo-4-phenyl-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-5-yl)oxy)acetamido)benzamide

参考文献

1. Yagmur Umay Doruk, et al. J Biol Chem. 2020 Mar 13;295(11):3518-3531.