CLK inhibitor 2 |CAS:1005776-20-4 Probechem Biochemicals

Chemical Structure : CLK inhibitor 2

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CLK inhibitor 2

货号: PC-61026Not For Human Use, Lab Use Only.

CLK inhibitor 2 is a potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively.

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生物&药学活性

CLK inhibitor 2 is a potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively.
CLK inhibitor 2 moderately inhibits PI3Kα, and >100-fold selectivity over SRPK1/2/3.
CLK inhibitor 2 inhibits phospho-SRSF4 in MDA-MB-468 cells, induces alternative splicing of the S6K pre-mRNA at 1.1-3.3 uM, exhibits growth inhibitory activity with GI50 of 3.0 uM, through splicing alterations in genes involved in growth and survival.

物理化学性质&存储条件

分子量	360.421
分子式	C20H20N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl)-6-(tert-butyl)nicotinamide

参考文献

1. Araki S, et al. PLoS One. 2015 Jan 12;10(1):e0116929.

2. Shi Y, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):406-412.

CLK inhibitor 2

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物理化学性质&存储条件

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CLK inhibitor 2

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物理化学性质&存储条件

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