CLK2 inhibitor LQ23 | CLK2 inhibitor | Probechem Biochemicals

Chemical Structure : CLK2 inhibitor LQ23

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CLK2 inhibitor LQ23 (LQ23)

货号: PC-22056Not For Human Use, Lab Use Only.

CLK2 inhibitor LQ23 is a potent, selective cdc2-like kinase 2 (CLK2) inhibitor with IC50 of 1.4 nM, >70-fold selecitve over CLK3.

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100 mg		Get quote

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生物&药学活性

CLK2 inhibitor LQ23 is a potent, selective cdc2-like kinase 2 (CLK2) inhibitor with IC50 of 1.4 nM, >70-fold selecitve over CLK3.
LQ23 also display high potency against CLK1, CLK4 with IC50 of 2.1 nM and 3.4 nM.
LQ23 dose-dependently inhibit SR protein phosphorylation (pSRSF4, pSRSF5, and pSRSF6) in chondrocytes.
LQ23 treatment dose-dependently inhibits CHIR99021 (GSK3β inhibitor)-stimulated Wnt signaling in HEK-293T cells with EC50 of 2.9 uM.
LQ23 (30 nM) promotes the differentiation of BMSCs into chondrocytes in vitro, protectes chondrocytes and BMSCs from catabolic breakdown.
LQ23 (30 nM) inhibits inflammatory response in chondrocytes, effectively inhibits the expression of TNF-α, IL-6, and IL-β in TNF-α and Oncostatin M-stimulated chondrocytes.
LQ23 (1.5 ug/kg, IA injection) inhibits inflammation, protected cartilage, and improved function in the monosodium iodoacetate (MIA)-induced rat knee OA model.

物理化学性质&存储条件

分子量	416.54
分子式	C24H24N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-Methyl-1-((5-(3-(thiophen-3-ylethynyl)-1H-indazol-5-yl)pyridin-3-yl)oxy)pentan-2-amine

参考文献

1. Yongqiang Sun, et al. J Med Chem. 2024 Mar 18.

CLK2 inhibitor LQ23 (LQ23)

生物&药学活性

物理化学性质&存储条件

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CLK2 inhibitor LQ23 (LQ23)

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