CLK2 inhibitor Indazole1 | CAS 2252153-37-8 Probechem Biochemicals

Chemical Structure : CLK2 inhibitor Indazole 1

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CLK2 inhibitor Indazole 1 (Indazole 1)

货号: PC-35359Not For Human Use, Lab Use Only.

CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM, 60-fold selectivity over PKA and >600-fold selectivity over a panel of 34 kinases.

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生物&药学活性

CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM, 60-fold selectivity over PKA and >600-fold selectivity over a panel of 34 kinases.
CLK2 inhibitor Indazole1 rescues spine density in mouse brain slices at 300 nM.
CLK2 inhibitor Indazole1 displays 96-fold more potent than TG003 in the CLK2 Caliper assay.

物理化学性质&存储条件

分子量	324.428
分子式	C19H24N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-methyl-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)pentan-2-amine

参考文献

1. Lerchner AM, et al. ChemMedChem. 2018 Jul 9. doi: 10.1002/cmdc.201800344.

CLK2 inhibitor Indazole 1 (Indazole 1)

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CLK2 inhibitor Indazole 1 (Indazole 1)

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