CLK1 inhibitor 25

Chemical Structure : CLK1 inhibitor 25

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货号: PC-21433Not For Human Use, Lab Use Only.

CLK1 inhibitor 25 is a potent and selective inhibitor of cdc2-like kinase 1 (CLK1) with IC50 of 2 nM, 69-fold selective over DYRK1A.

规格	价格	库存	数量
5 mg		Get quote
10 mg		Get quote
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

CLK1 inhibitor 25 is a potent and selective inhibitor of cdc2-like kinase 1 (CLK1) with IC50 of 2 nM, 69-fold selective over DYRK1A.
CLK1 inhibitor 25 also potently inhibits CLK2 (IC50: 31 nM) and CLK4 (IC50: 8 nM).
CLK1 inhibitor 25 displays at least 110-fold selectivity toward CLK1 over 351 of the 357 kinases tested (98.32%), does not show obvious activity against 292 kinases (IC50>10 μM).
CLK1 inhibitor 25 (10 uM) alters the location and redistribution of SR proteins in BNL CL.2 cells.
CLK1 inhibitor 25 induces autophagy in in vitro assays and displays significant hepatoprotective effects in the acetaminophen (APAP)-induced liver injury mouse model.

物理化学性质&存储条件

分子量	409.42
分子式	C24H16FN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-(1-(1-(4-fluorophenyl)ethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-8-yl)benzo[d]oxazole

参考文献

1. Sun QZ, et al. J Med Chem. 2017 Jul 27;60(14):6337-6352.