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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Mixed Lineage Kinase (MLK)-CLFB-1134
CLFB-1134

Chemical Structure : CLFB-1134

CAS No.: 1627729-62-7

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CLFB-1134 (CLFB1134)

货号: PC-23625Not For Human Use, Lab Use Only.

CLFB-1134 is a potent, specific and brain-penetrant inhibitor of mixed lineage kinase-3 (MLK3) with IC50 of 42 nM.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2680 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CLFB-1134 is a potent, specific and brain-penetrant inhibitor of mixed lineage kinase-3 (MLK3) with IC50 of 42 nM.
CLFB-1134 decreases phosphorylation of JNK in the midbrain.
CLFB-1134 protects nigral dopamine neurons and striatal dopamine terminals in neurotoxin mouse model of Parkinson's disease.

物理化学性质&存储条件

分子量 432.50
分子式 C23H20N4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3,4-dimethoxyphenyl)-3-(7-methoxybenzo[b]thiophen-2-yl)imidazo[1,2-b]pyridazin-6-amine

参考文献

1. Kline EM, et al. Exp Neurol. 2019 Aug;318:157-164.

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