CLC-2-IN-AK42 | CLC-2 inhibitor | Probechem Biochemicals

Chemical Structure : CLC-2-IN-AK42

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CLC-2-IN-AK42 (CLC-2 inhibitor AK42, AK42)

货号: PC-72552Not For Human Use, Lab Use Only.

CLC-2-IN-AK42 (CLC-2 inhibitor AK42, AK42) is a potent, specific small-molecule inhibitor of voltage-gated chloride channel CLC-2 with IC50 of 17 nM (human CLC-2).

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生物&药学活性

CLC-2-IN-AK42 (CLC-2 inhibitor AK42, AK42) is a potent, specific small-molecule inhibitor of voltage-gated chloride channel CLC-2 with IC50 of 17 nM (human CLC-2).
AK42 displays unprecedented selectivity (>1,000-fold) over CLC-1, the closest CLC-2 homolog, and no off-target engagement a diverse panel of 61 CNS receptors, channels, and transporters expressed in brain tissue.
AK-42 binds to an extracellular vestibule above the channel pore.
AK-42 is almost three orders-of-magnitude more potent than MCFA, demonstrates high potency (IC50=14 nM for rat CLC-2) in manual patch-clamp experiments on CHO cells transiently transfected with rat CLC-2.
AK-42 inhibits hyperpolarization-activated current in hippocampal cells, attenuates steady-state currents and eliminated relaxation currents in recorded neurons.
AK-42 is a powerful tool for investigating CLC-2 neurophysiology.

物理化学性质&存储条件

分子量	389.232
分子式	C19H14Cl2N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3-(benzyloxy)-2,6-dichlorophenyl)amino)nicotinic acid

参考文献

1. Anna K Koster, et al. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32711-32721.

CLC-2-IN-AK42 (CLC-2 inhibitor AK42, AK42)

生物&药学活性

物理化学性质&存储条件

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CLC-2-IN-AK42 (CLC-2 inhibitor AK42, AK42)

生物&药学活性

物理化学性质&存储条件

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