CL-387785 |CAS:194423-06-8 Probechem Biochemicals

Chemical Structure : CL-387785

CAS No.: 194423-06-8

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CL-387785 (EKI-785;WAY-EKI 785;CL387785;CL 387785;EKI785;WAY-EKI785;EKI 785)

货号: PC-42524Not For Human Use, Lab Use Only.

CL-387785 (EKI785, WAY-EKI785) is a specific, irreversible, covalent EGFR inhibitor with IC50 of 0.37 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

CL-387785 (EKI785, WAY-EKI785) is a specific, irreversible, covalent EGFR inhibitor with IC50 of 0.37 nM.
CL-387785 blocks EGF-stimulated autophosphorylation of EGFR in A431 cells (IC50=5 nM).
CL-387785 inhibits cell proliferation (IC50= 31-125 nM) primarily in a cytostatic manner in cell lines that overexpress EGF-R or c-ErbB2, and profoundly blocks the growth of a tumor that overexpresses EGFR in nude mice; orally active.

物理化学性质&存储条件

分子量	381.226
分子式	C18H13BrN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 13.67 mg/mL
Chemical Name/SMILES	2-Butynamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-

参考文献

1. Discafani CM, et al. Biochem Pharmacol. 1999 Apr 15;57(8):917-25.

2. Kobayashi S, et al. Cancer Res. 2005 Aug 15;65(16):7096-101.

3. Kobayashi S, et al. Cancer Res. 2006 Dec 1;66(23):11389-98.

CL-387785 (EKI-785;WAY-EKI 785;CL387785;CL 387785;EKI785;WAY-EKI785;EKI 785)

生物&药学活性

物理化学性质&存储条件

参考文献

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CL-387785 (EKI-785;WAY-EKI 785;CL387785;CL 387785;EKI785;WAY-EKI785;EKI 785)

生物&药学活性

物理化学性质&存储条件

参考文献

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