CK-571 (CK-2018571) | Smooth muscle myosin inhibitor | Probechem Biochemicals

Chemical Structure : CK-571

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CK-571 (CK-2018571, CK571, CK2018571)

货号: PC-26090Not For Human Use, Lab Use Only.

CK-571 (CK-2018571) is a potent and selective inhibitor of Smooth muscle myosin-2 (SMM) with IC50 of 86 nM.

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生物&药学活性

CK-571 (CK-2018571) is a potent and selective inhibitor of Smooth muscle myosin-2 (SMM) with IC50 of 86 nM.
CK-571 specifically inhibits the steady-state actin-activated MgATPase activity of SMM with IC50 of 9 nM, over other Myosin II isoforms (cardiac and striated muscle myosins).
CK-571 also has a significantly lower affinity for nonmuscle myosin II (NMM, ∼8.5-fold less).
CK-571 binds to an allosteric pocket that becomes momentarily available during one of the intermediate steps of the recovery stroke of the myosin motor.

物理化学性质&存储条件

分子量	504.94
分子式	C24H26ClFN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-2-(3-(2-chloro-3-fluorobenzyl)-1-methylureido)-4,5-dihydroxypentyl isoquinolin-3-ylcarbamate

参考文献

1. Suthar SK, et al. Eur J Med Chem. 2026 Mar 5;305:118476.

2. Serena Sirigu, et al. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7448-E7455.

CK-571 (CK-2018571, CK571, CK2018571)

生物&药学活性

物理化学性质&存储条件

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CK-571 (CK-2018571, CK571, CK2018571)

生物&药学活性

物理化学性质&存储条件

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