Reldesemtiv (CK-2127107) | Fast skeletal troponin activator

Chemical Structure : CK-2127107

CAS No.: 1345410-31-2

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CK-2127107 (CK-107, Reldesemtiv)

货号: PC-60222Not For Human Use, Lab Use Only.

CK-2127107 (CK-107, Reldesemtiv) is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.

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5 mg	￥2980	In stock
10 mg	￥4580	In stock
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生物&药学活性

CK-2127107 (CK-107, Reldesemtiv) is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.
CK-2127107 (CK-107, Reldesemtiv) has no effect on slow skeletal or cardiac myofibrils.
CK-2127107 (CK-107, Reldesemtiv) significantly improves rotarod performance in exercise-intolerant LAD-HF rats.

物理化学性质&存储条件

分子量	384.391
分子式	C19H18F2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[2-({[trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutyl]methyl}amino)pyrimidin-5-yl]-1H-pyrrole-3-carboxamide

参考文献

1. Hwee DT, et al. J Pharmacol Exp Ther. 2015 Apr;353(1):159-68.

2. Calder AN, et al. J Med Chem. 2016 Nov 23;59(22):10067-10083.

CK-2127107 (CK-107, Reldesemtiv)

生物&药学活性

物理化学性质&存储条件

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CK-2127107 (CK-107, Reldesemtiv)

生物&药学活性

物理化学性质&存储条件

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