CK-0106023 |CAS:336115-72-1 Probechem Biochemicals

Chemical Structure : CK-0106023

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CK-0106023 (CK 0106023;CK0106023)

货号: PC-70048Not For Human Use, Lab Use Only.

CK-0106023 (CK0106023) is a potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM.

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生物&药学活性

CK-0106023 (CK0106023) is a potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM.
CK-0106023 displays >200-fold selectivity over the mitotic kinesins CENP-E, MKLP1 and Kif1A.
CK-0106023 causes mitotic arrest and growth inhibition in several human tumor cell lines.
CK-0106023 exhibits antitumor activity in tumor-bearing mice.

物理化学性质&存储条件

分子量	595.96
分子式	C30H32BrClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)-4-bromo-N-(3-(dimethylamino)propyl)benzamide

参考文献

1. Sakowicz R, et al. Cancer Res. 2004 May 1;64(9):3276-80.

2. Zhang B, et al. Anal Biochem. 2005 Oct 15;345(2):326-35.

CK-0106023 (CK 0106023;CK0106023)

生物&药学活性

物理化学性质&存储条件

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CK-0106023 (CK 0106023;CK0106023)

生物&药学活性

物理化学性质&存储条件

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