CJB 090 | D3 receptor agonist | Probechem Biochemicals

Chemical Structure : CJB 090

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CJB 090 (CJB090)

货号: PC-20864Not For Human Use, Lab Use Only.

CJB 090 (CJB090) is a selective partial agonist of dopamine D3 receptor with binding Ki of 0.6 nM, CJB 090 is 97-fold selective for D3 receptors over D2.

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生物&药学活性

CJB 090 (CJB090) is a selective partial agonist of dopamine D3 receptor with binding Ki of 0.6 nM, CJB 090 is 97-fold selective for D3 receptors over D2.
CJB 090 significantly attenuates cocaine's discriminative stimulus effects in cocaine discrimination studies.
CJB 090 also significantly attenuates the partial cocaine-like stimulus effects of the preferential D3 receptor agonist PD 128907 but not the preferential D2 receptor agonist sumanirole.
CJB 090 does not attenuate either self-administration of cocaine or cocaine-induced reinstatement of extinguished drug-seeking at a dose that reduced responding maintained by food.
CJB 090 does not induce scratching or biting (species-typical effects of D2/3 receptor agonists) or catalepsy (typical effect of D2/3 receptor antagonists).

物理化学性质&存储条件

分子量	483.44
分子式	C26H28Cl2N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide

参考文献

1. Achat-Mendes C, et al. Psychopharmacology (Berl). 2009 Sep;206(1):73-84.

2. Newman AH, et al. Bioorg Med Chem Lett. 2003;13:2179–2183.

CJB 090 (CJB090)

生物&药学活性

物理化学性质&存储条件

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CJB 090 (CJB090)

生物&药学活性

物理化学性质&存储条件

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