CJ-042794 |CAS:847728-01-2 Probechem Biochemicals

Chemical Structure : CJ-042794

CAS No.: 847728-01-2

加入收藏

CJ-042794 (CJ-42794;CJ42794;CJ 042794)

货号: PC-42700Not For Human Use, Lab Use Only.

CJ-042794 (CJ-42794) is a potent, selective prostaglandin E receptor subtype 4 (EP4) antagonist with pKi of 8.5.

规格	价格	库存
50 mg	￥1880	In stock
100 mg	￥3180	In stock
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CJ-042794 (CJ-42794) is a potent, selective prostaglandin E receptor subtype 4 (EP4) antagonist with pKi of 8.5.
CJ-042794 displays >200-fold more selective for human EP4 receptor than EP1, EP2, and EP3.
CJ-042794 competitively inhibits PGE2-evoked elevations of intracellular cAMP levels in HEK293 cells overexpressing EP4 receptor with a mean pA(2) value of 8.6.
CJ-042794 reverses the inhibitory effects of PGE2 on LPS-induced TNFα production.

物理化学性质&存储条件

分子量	413.8261
分子式	C22H17ClFNO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 28 mg/mL
Chemical Name/SMILES	Benzoic acid, 4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]-

参考文献

1. Takeuchi K, et al. J Pharmacol Exp Ther. 2007 Sep;322(3):903-12.

2. Murase A, et al. Life Sci. 2008 Jan 16;82(3-4):226-32.

3. Murase A, et al. Eur J Pharmacol. 2008 Feb 2;580(1-2):116-21.

CJ-042794 (CJ-42794;CJ42794;CJ 042794)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CJ-042794 (CJ-42794;CJ42794;CJ 042794)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.