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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-CIRc-028
CIRc-028

Chemical Structure : CIRc-028

CAS No.: 3036232-03-5

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CIRc-028 (CIRc028)

货号: PC-25359Not For Human Use, Lab Use Only.

CIRc-028 is a potent, in vivo-active, orally bioavailable dual cyclin A/B RxL inhibitor, inhibits cyclin A/B-RxL interactions and induces apoptosis in cancer cells with high E2F activity, induced spindle assembly checkpoint (SAC) activation and apoptosis in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CIRc-028 is a potent, in vivo-active, orally bioavailable dual cyclin A/B RxL inhibitor, inhibits cyclin A/B-RxL interactions and induces apoptosis in cancer cells with high E2F activity, induced spindle assembly checkpoint (SAC) activation and apoptosis in vivo.

物理化学性质&存储条件

分子量 976.93
分子式 C45H63Cl2F4N7O8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S,4R)-N-((S)-3-cyclobutyl-1-(((6S,9S,12S)-6-(2,5-dichlorobenzyl)-9-isobutyl-5,8,11,18-tetraoxo-7-propyl-4,7,10,17-tetraazaspiro[2.15]octadecan-12-yl)(methyl)amino)-1-oxopropan-2-yl)-4-fluoro-1-((R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl)pyrrolidine-2-carboxamide

参考文献

1. Singh S, et al. Nature. 2025 Aug 20. doi: 10.1038/s41586-025-09433-w.

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